Expected use
The One Step Troponin I Test (WB / S / P) is a rapid chromatographic immunoassay for the qualitative detection of human cardiac troponin I in whole blood, serum, or plasma as an aid in the diagnosis of myocardial infarction (MI).
Summary and explanation
Cardiac troponin I (cTnI) is a protein found in heart muscle with a molecular weight of 22.5 kDa. Troponin I is part of a three-subunit complex comprising troponin T and troponin C. Together with tropomyosin, this structural complex forms the main component that regulates the calcium-sensitive ATPase activity of actomyosin in skeletal and skeletal muscle. cardiac. After cardiac injury occurs, troponin I is released into the blood 4-6 hours after pain onset and remains elevated for 6-10 days, thus providing a longer window of detection of cardiac injury.
The high specificity of cTnI measurements for the identification of myocardial damage has been demonstrated in conditions such as the perioperative period, after marathon races, and blunt chest trauma. Release of cTnI has also been documented in heart conditions other than acute myocardial infarction (AMI), such as unstable angina, congestive heart failure, and chemical damage due to coronary artery bypass surgery. Due to its high specificity and sensitivity in myocardial tissue, troponin I has recently become the most preferred biomarker for myocardial infarction.
