Zika Virus IGG/IGM Antibody

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ZIK 498
Packing Size:
Whole Blood/Serum
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Expected use

Atlas Link One Step Zika IgG / IgM Antibody Test is a rapid, qualitative and convenient in vitro immunochromatographic assay for the deferent detection of IgG and IgM antibodies against Zika virus in human serum, plasma and / or whole blood samples. This test only provides a preliminary result. Clinical experience and professional judgment should be sought to further evaluate the test result.

Summary and explanation

Zika virus, first isolated in Uganda from a sentinel monkey in 1947, is an emerging arthropod-borne virus (arbovirus) carried by Aedes mosquitoes (Stegomyia). The virus belongs to the genus Flavivirus, family Flaviviridae, and is related to the dengue virus, which has a similar epidemiology and transmission cycle in urban settings. In the past, only sporadic Zika virus infections have been reported in humans. Serological studies and virus isolates have shown that the virus has a wide geographic distribution, including East and West Africa, the Indian subcontinent, Southeast Asia, and, more recently, South America. Symptoms include arthralgia, edema of the extremities, mild fever, frequently itchy maculopapular rashes, headaches, retroorbital pain, non-purulent conjunctivitis, vertigo, myalgia, and digestive disorders. The clinical symptoms of Zika disease appear after an incubation period that ranges from three to twelve days. Symptoms are usually mild and short-lived, ranging from two to seven days.

The infection can go unnoticed or be misdiagnosed as dengue. Diagnosis of Zika virus infection includes PCR tests to detect viral DNA, as well as additional tests to detect Zika virus antibodies (IgM) in serum. IgM for Zika virus is usually detected within three to five days after infection, but cross-reactivity with closely related dengue, yellow fever, Japanese encephalitis, and West Nile viruses is possible. . However, these cross-reactive results have been found to be more common in patients denoting signs of previous flavivirus infections than in patients with primary Zika virus infection. For more efficient diagnosis, serum samples should be analyzed as soon as possible, with a second test two to three weeks later. Different profiles of humoral immune responses in primary and secondary Zika viral infections can be used for differential diagnosis. The presence of high titers of IgG antibodies does not interfere with the detection of IgM antibodies in the sample.