MOTS-c Antibody

Species Reactivity Human, Rat

Host/Isotype Rabbit / IgG

Class Polyclonal

Type Antibody

Immunoge Full-length peptide corresponding to amino acids 1-16 on MOTS-c.

Conjugate Unconjugated

Form Liquid

Concentration 0.5-1.5 mg/mL

Purification Affinity chromatography

Storage buffer proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains 0.02% sodium azide

Storage conditions -20°C

Target Information

Regulates insulin sensitivity and metabolic homeostasis. Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity.