Affinity chromatography purified via peptide column
Applications:
ELISA WB
Species Reactivity:
Hu Ms
Specificity:
At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.
Immunogen Type:
Peptide
Immunogen Description:
19 amino acid peptide near the center of human SHANK3.
Target Name:
SHANK3
Accession No.:
Swiss-Prot:Q9BYB0
Concentration:
1mg/ml
Formulation:
PBS containing 0.02% sodium azide.
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year.
Molecular Weight:
190 kDa
Antigen:
Synthetic peptide amino acids 840-857 (PEKLPGSLRKGIPRTKSV) of rat Shank3 (also known as SH3 and multiple ankyrin repeat domains protein 3, prolinerich synapse-associated protein 2, ProSAP2 and SPANK-2, accession number Q9JLU4); Human: 100% identity (18/18 amino acids identical); Mouse: 100% identity (18/18 amino acids identical)
Synonyms:
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Target Description:
SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density.
Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.
